- Sales & Marketing Consultant, Holtsville
- Sand Gravel & Aggregate, Holtsville
- Sandwich Shop Restaurants, Holtsville
- Scientific & Laboratory Equipment & Instruments, Holtsville
- Security & Surveillance System & Equipment, Holtsville
- Security Brokers & Dealers, Holtsville
- Security Services, Holtsville
- Septic & Cesspool Building & Service, Holtsville
- Sheet Metal Contractors, Holtsville - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, Holtsville
- Shopping & Shopping Services, Holtsville
- Siding Contractors, Holtsville - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Small Appliances, Holtsville
- Snow Removal Services, Holtsville - Snow Plow Service
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- Social Services & Welfare, Holtsville
- Special Events & Party Supply Rental, Holtsville
- Special Interest Schools Or Instruction, Holtsville
- Specialty Stores, Holtsville
- Staffing & Support Services, Holtsville
- Stationery & Office Supplies, Holtsville
- Stock & Bond Brokers & Dealers, Holtsville
- Stocks & Bond Brokers, Holtsville
- Swimming Pool Covers & Enclosures, Holtsville
- Swimming Pool, Sauna & Spa Contractors, Holtsville
- Swimming Pools, Holtsville
- Swimming Pools Contractors, Holtsville - Install Inground - Above Ground Pools
- Swimming Pools Repair, Service, Supplies, Sale & Installation, Holtsville
- Swimming Pools Supplies, Equipment & Accessories, Holtsville
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