- Sandwich Shop Restaurants, Le Roy
- Satellite Dish Antennas & Equipment Dealers, Le Roy
- Satellite TV Service, Le Roy
- Screen Printing, Le Roy
- Secondary Schools, Le Roy
- Security & Surveillance System & Equipment, Le Roy
- Security Brokers & Dealers, Le Roy
- Security Services, Le Roy
- Senior Citizens Service & Health Organizations, Le Roy
- Shirts & T-Shirts, Le Roy
- Shopping & Shopping Services, Le Roy
- Signs, Le Roy
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- Snow Removal Services, Le Roy - Snow Plow Service
- Social Clubs & Organizations, Le Roy
- Social Services & Welfare, Le Roy
- Societies & Foundation Associations, Le Roy
- Special Coatings, Le Roy - Protective Coatings
- Special Interest Schools Or Instruction, Le Roy
- Specialty Stores, Le Roy
- Sporting Goods Stores, Le Roy
- Staffing & Support Services, Le Roy
- Stamp Collecting & Coin Dealers , Le Roy
- State Government, Le Roy
- Steel & Metal Goods, Le Roy - Steel Distributors
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