- Obstetricians & Gynecologists, Wellsville - Ob-Gyn Doctors, Physicians & Surgeons (Obstetrics & Gynecology)
- Off Road Vehicles, Wellsville
- Off Road Vehicles Parts & Accessories, Wellsville
- Oil & Gas Exploration & Development, Wellsville - Oil Field Exploration, Monitoring & Remediation
- Oil Industry & Oil Field Equipment & Services, Wellsville - Oil Companies
- Oil Refinery, Wellsville
- Optical Stores - Eyeglasses, Lenses & Sunglasses, Wellsville
- Opticians, Wellsville
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- Optometrists, Wellsville - Eye Doctors, Physicians & Surgeons (Optometry)
- Ornamental Nursery, Wellsville
- Ornamental Nursery Services, Wellsville
- Orthodontist, Wellsville - Teeth Straightening, Invisalign & Dental Braces
- Other Building Materials & Supplies, Wellsville
- Outdoor Equipment & Accessories, Wellsville
- Outdoor Furniture & Patio Furniture, Wellsville - Garden Furniture Stores
- Oxygen & Respiratory Equipment & Supplies, Wellsville - Oxygen Concentrator, Tank, Machine, etc
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