- Dance Companies, Williamsville
- Data Processing Services, Williamsville
- Day Spas, Williamsville
- Deck, Patio & Gazebo Design, Building, Cleaning, Repair & Maintenance Contractors, Williamsville
- Decorating & Designing Services, Williamsville
- Delicatessen Restaurants, Williamsville
- Dentists, Williamsville
- Department Stores, Williamsville
- Dermatologists, Williamsville - Skin Doctors, Physicians & Surgeons (Dermatology)
- Dialysis Clinics, Williamsville - Kidney Dialysis Centers
- Diet Center, Williamsville
- Diet Centers, Williamsville
- Digital Printers, Williamsville
- Digital Printing & Imaging Service, Williamsville
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- Diner Restaurants, Williamsville
- Direct Mail Advertising Services, Williamsville
- Disc Jockeys, Williamsville
- Doctorate Degree, Williamsville
- Doctors, Physicians & Surgeons, Williamsville
- Dolls, Doll Houses & Accessories , Williamsville
- Donuts, Williamsville
- Doors & Door Frames, Williamsville - Exterior, Interior, French, Front Entry, Patio, Storm, Garage & Sliding Glass Doors
- Drafting Services, Williamsville
- Drinking Establishments, Williamsville
- Dry Cleaning & Laundry, Williamsville - Dry Cleaners
- Durable & Non Durable Goods & Products, Williamsville
- Durable Goods & Products, Williamsville
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