- Laboratories Medical, Depew
- Laboratory Equipment Repair & Service, Depew
- Landscape Contractors & Designers, Depew
- Landscaping, Depew
- Laser Equipment Repair & Service, Depew
- Laundry Equipment Rental & Leasing, Depew
- Lawn & Garden Services, Depew
- Lawn Maintenance Services, Depew
- Lawn Mower Repair & Blade Sharpening Service, Depew
- Lawyers & Attorneys, Depew
- Legal & Tax Services, Depew
- Legal Professionals, Depew
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- Letter Shop & Addressing Services, Depew
- Limousine Service, Depew
- Liquor Stores, Depew
- Locks, Depew
- Locksmiths, Depew - Residence, Commercial, Safe & Auto Car Locksmith
- Locksmiths Equipment & Supplies, Depew
- Lodging, Depew
- Long Haul Trucking Companies, Depew
- Lumber & Lumber Products, Depew
- Lumber & Lumber Products, Depew
- Lutheran Church, Depew
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