- Sandwich Shop Restaurants, East Islip
- Savings Banks, East Islip
- Screen Printing, East Islip
- Security & Surveillance System & Equipment, East Islip
- Security Services, East Islip
- Sewer & Drain Cleaning & Repair, East Islip - Drain Cleaner & Installation Services
- Shooting & Target Ranges, East Islip
- Shopping & Shopping Services, East Islip
- Siding Contractors, East Islip - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Snacks & Desserts, East Islip
- Social Services & Welfare, East Islip
- Social Workers & Services, East Islip
- Societies & Foundation Associations, East Islip
- Special Events & Party Supply Rental, East Islip
- Special Interest Schools Or Instruction, East Islip
- Specialty Animal Services, East Islip
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- Specialty Stores, East Islip
- Speech & Hearing Specialists, East Islip
- Sporting Goods Equipment Rental, East Islip
- Sporting Goods Stores, East Islip
- Sprinkler System Contractors, East Islip - Garden & Lawn Sprinkler System Installation & Repair
- Stamp Collecting & Coin Dealers , East Islip
- State Government, East Islip
- Stationery & Office Supplies, East Islip
- Surfboard & Windsurfing Equipment Shops, East Islip
- Surgical Supplies & Equipment, East Islip
- Surgical Supplies, Instruments, Tools & Equipment, East Islip
- Surveyor Services, East Islip - Surveying Service
- Swimming Pool, Sauna & Spa Contractors, East Islip
- Swimming Pools Contractors, East Islip - Install Inground - Above Ground Pools
- Swimming Pools Repair, Service, Supplies, Sale & Installation, East Islip
- Swimming Pools Supplies, Equipment & Accessories, East Islip
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