- Sandwich Shop Restaurants, Mechanicville
- Sealcoating, Mechanicville - Asphalt Sealcoating & Paving
- Secondary Schools, Mechanicville
- Security & Surveillance System & Equipment, Mechanicville
- Security Services, Mechanicville
- Senior Citizens Service & Health Organizations, Mechanicville
- Sheet Metal Contractors, Mechanicville - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, Mechanicville
- Shoe Repair & Shoeshine Parlors, Mechanicville
- Shoe Repair Shops, Mechanicville
- Shopping & Shopping Services, Mechanicville
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- Siding Contractors, Mechanicville - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Small Appliances, Mechanicville
- Snack Foods, Mechanicville
- Snow Removal Services, Mechanicville - Snow Plow Service
- Social Services & Welfare, Mechanicville
- Societies & Foundation Associations, Mechanicville
- Specialty Animal Services, Mechanicville
- Specialty Stores, Mechanicville
- Sporting Goods Stores, Mechanicville
- State Government, Mechanicville
- Support Services, Mechanicville
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