- Sales & Marketing Consultant, North Tonawanda
- Sand Gravel & Aggregate, North Tonawanda
- Sandwich Shop Restaurants, North Tonawanda
- Savings & Loan Associations, North Tonawanda
- Savings Banks, North Tonawanda
- Science & Research, North Tonawanda
- Scientific & Laboratory Equipment & Instruments, North Tonawanda
- Scrap & Waste Materials, North Tonawanda
- Screen Printing, North Tonawanda
- Seafood Restaurants, North Tonawanda
- Security & Surveillance System & Equipment, North Tonawanda
- Security Alarm Systems - Home & Business, North Tonawanda
- Security Control Systems & Monitoring, North Tonawanda - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Investigative Services, North Tonawanda
- Security Services, North Tonawanda
- Senior Citizens Information & Services, North Tonawanda
- Senior Citizens Service & Health Organizations, North Tonawanda
- Septic Tanks & Systems, North Tonawanda - Wholesale, Dealers & Suppliers
- Sewer & Drain Cleaning & Repair, North Tonawanda - Drain Cleaner & Installation Services
- Sewing & Yarn Stores & Supplies, North Tonawanda
- Sheet Metal, North Tonawanda
- Sheet Metal Contractors, North Tonawanda - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, North Tonawanda
- Sheet Metal Fabricators Equipment & Supplies Manufacturers, North Tonawanda
- Shoe Store - More, North Tonawanda
- Shoe Stores, North Tonawanda - Mens, Womens & Kids Shoes
- Shopping & Shopping Services, North Tonawanda
- Siding Contractors, North Tonawanda - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Sightseeing Tours, North Tonawanda
- Signs, North Tonawanda
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- Small Appliances, North Tonawanda
- Snow Removal Services, North Tonawanda - Snow Plow Service
- Social Clubs & Organizations, North Tonawanda
- Social Service Organizations Mental Health Services, North Tonawanda
- Social Service Organizations Volunteer Services, North Tonawanda
- Social Services & Welfare, North Tonawanda
- Special Dies Tools Jigs & Fixtures Manufacturers, North Tonawanda
- Special Education & Care, North Tonawanda
- Special Interest Schools Or Instruction, North Tonawanda
- Specialty Animal Services, North Tonawanda
- Specialty Stores, North Tonawanda
- Sporting Goods Equipment Rental, North Tonawanda
- Sporting Goods Stores, North Tonawanda
- Sports & Recreational Services, North Tonawanda
- Sports Bars & Lounges, North Tonawanda
- Sportswear Clothing Stores, North Tonawanda - Sports Clothes
- Sprinkler System Contractors, North Tonawanda - Garden & Lawn Sprinkler System Installation & Repair
- Staffing & Support Services, North Tonawanda
- Stairs & Railings Contractors, North Tonawanda - Metal & Wood Stairs, Spiral Staircase & Stair Railing - Installation & Repair
- Stairs, Balcony, Terrace & Steeple Contractors, North Tonawanda
- State Government, North Tonawanda
- Steel & Metal Goods, North Tonawanda - Steel Distributors
- Steel Manufacturers, North Tonawanda
- Steel Mills & Blast Furnaces, North Tonawanda
- Store Fronts, North Tonawanda - Storefront
- Stove, Oven, Range & Cooktop Parts & Supplies, North Tonawanda
- Submarine Sandwich Restaurants, North Tonawanda
- Sunrooms & Solarium Construction Contractors, North Tonawanda - Build & Repair
- Sunrooms, Greenhouses, Solariums & Atrium Builders, North Tonawanda - Build & Repair
- Surveyor Services, North Tonawanda - Surveying Service
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