- Safe & Vault, Port Jefferson
- Safety & Security Systems & Consultants, Port Jefferson
- Sandwich Shop Restaurants, Port Jefferson
- Satellite & Cable TV Equipment & Systems, Port Jefferson
- Satellite Communication Downlinking & Uplinking, Port Jefferson
- Satellite TV Service, Port Jefferson
- Screen Printing, Port Jefferson
- Secondary Schools, Port Jefferson
- Secretarial & Court Reporting Services, Port Jefferson
- Security & Surveillance System & Equipment, Port Jefferson
- Security Alarm Systems - Home & Business, Port Jefferson
- Security Brokers & Dealers, Port Jefferson
- Security Control Systems & Monitoring, Port Jefferson - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Investigative Services, Port Jefferson
- Security Services, Port Jefferson
- Septic & Cesspool Building & Service, Port Jefferson
- Sewer & Drain Cleaning & Repair, Port Jefferson - Drain Cleaner & Installation Services
- Sewing & Yarn Stores & Supplies, Port Jefferson
- Shells Marine, Port Jefferson
- Shopping & Shopping Services, Port Jefferson
- Siding Contractors, Port Jefferson - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Skating Rink & Hockey Operation Services, Port Jefferson
- Sleep Disorders Treatment & Information Centers, Port Jefferson
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- Snacks & Desserts, Port Jefferson
- Snow Removal Services, Port Jefferson - Snow Plow Service
- Social Clubs & Organizations, Port Jefferson
- Social Services & Welfare, Port Jefferson
- Social Workers & Services, Port Jefferson
- Societies & Foundation Associations, Port Jefferson
- Soil Testing Labs, Port Jefferson - Concrete Testing
- Specialty Animal Services, Port Jefferson
- Specialty Stores, Port Jefferson
- Speech & Hearing Specialists, Port Jefferson
- Speech Pathologists, Port Jefferson - Speech & Language Therapy
- Sporting Goods Stores, Port Jefferson
- Sportswear Clothing Stores, Port Jefferson - Sports Clothes
- Sprinkler System Contractors, Port Jefferson - Garden & Lawn Sprinkler System Installation & Repair
- Staffing & Support Services, Port Jefferson
- Stamp Collecting & Coin Dealers , Port Jefferson
- State Government, Port Jefferson
- Steak House Restaurants, Port Jefferson
- Stocks & Bond Brokers, Port Jefferson
- Stoves & Furnace Equipment, Port Jefferson - Fittings & Repair Parts
- Structural Engineer, Port Jefferson
- Swimming Pools Repair, Service, Supplies, Sale & Installation, Port Jefferson
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