- Sandwich Shop Restaurants, West Islip
- Satellite Descrambling & Programming Service, West Islip
- Satellite Dish Antennas & Equipment Dealers, West Islip
- Satellite TV Service, West Islip
- Savings Banks, West Islip
- School - Catholic, West Islip
- School - Christian, West Islip
- Seafood Restaurants, West Islip
- Secondary Schools, West Islip
- Security & Surveillance System & Equipment, West Islip
- Security Brokers & Dealers, West Islip
- Security Services, West Islip
- Septic & Cesspool Building & Service, West Islip
- Septic Tank Installation & Repair, West Islip - Septic Systems
- Septic Tank Pumping & Cleaning, West Islip - Septic Systems
- Septic Tanks & Septic Systems Contractors, West Islip - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Septic Tanks & Systems, West Islip - Wholesale, Dealers & Suppliers
- Sewer & Drain Cleaning & Repair, West Islip - Drain Cleaner & Installation Services
- Sewer Construction Contractors, West Islip - Sewer Line, Pipe Installation & Repair Services
- Sharpening Service, West Islip
- Shoe Dyers, West Islip
- Shoe Repair Shops, West Islip
- Shopping & Shopping Services, West Islip
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- Shutters - Interior & Exterior, West Islip - Wood, Vinyl, Window, Plantation Shutters, etc
- Skin Care & Cosmetology Salons, West Islip
- Skin Care Products & Treatments, West Islip
- Small Appliances, West Islip
- Snacks & Desserts, West Islip
- Snow Removal Services, West Islip - Snow Plow Service
- Social Clubs & Organizations, West Islip
- Social Services & Welfare, West Islip
- Social Workers & Services, West Islip
- Special Events & Party Supply Rental, West Islip
- Special Interest Schools Or Instruction, West Islip
- Specialty Animal Services, West Islip
- Specialty Stores, West Islip
- Sporting & Recreational Camps, West Islip
- Sporting Goods Stores, West Islip
- Sports Clubs, West Islip
- Sprinkler System Contractors, West Islip - Garden & Lawn Sprinkler System Installation & Repair
- Stationery & Office Supplies, West Islip
- Stock Exchanges, West Islip
- Store Fronts, West Islip - Storefront
- Structural Engineer, West Islip
- Surgical Hospitals, West Islip - Surgical Centers
- Sushi Restaurants, West Islip
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