- Safety & Security Systems & Consultants, Yaphank
- Salvage Yards, Junk Yards & Wrecker Service, Yaphank
- Sand Gravel & Aggregate, Yaphank
- Satellite & Cable TV Equipment & Systems, Yaphank
- Satellite Dish Antennas & Equipment Dealers, Yaphank
- Screen Printing, Yaphank
- Security & Surveillance System & Equipment, Yaphank
- Security Management Consultants, Yaphank
- Security Services, Yaphank
- Service Establishment Supplies & Equipment, Yaphank
- Sewer & Drain Cleaning & Repair, Yaphank - Drain Cleaner & Installation Services
- Sheet Metal, Yaphank
- Sheriff's Department, Yaphank
- Shooting & Target Ranges, Yaphank
- Shopping & Shopping Services, Yaphank
- Siding Contractors, Yaphank - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
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- Signs, Yaphank
- Social Clubs & Organizations, Yaphank
- Social Services & Welfare, Yaphank
- Societies & Foundation Associations, Yaphank
- Special Events & Party Supply Rental, Yaphank
- Specialty Animal Services, Yaphank
- Specialty Stores, Yaphank
- Speech & Hearing Specialists, Yaphank
- Speech Pathologists, Yaphank - Speech & Language Therapy
- Sports Clubs, Yaphank
- Sprinkler Alarm Systems, Yaphank - Fire Sprinkler Systems
- Steel & Metal Goods, Yaphank - Steel Distributors
- Storage & Closet Equipment Supplies & Materials, Yaphank
- Sunrooms & Solarium Construction Contractors, Yaphank - Build & Repair
- Sunrooms, Greenhouses, Solariums & Atrium Builders, Yaphank - Build & Repair
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