- Day Spas, Central Islip
- Decals, Central Islip
- Delicatessen Restaurants, Central Islip
- Delivery & Errand Services, Central Islip
- Denomination, Non-Denominational, Etcetera, Central Islip
- Dentists, Central Islip
- Department Stores, Central Islip
- Digital Printing & Imaging Service, Central Islip
- Diner Restaurants, Central Islip
- Disc Jockeys, Central Islip
- Discount Stores, Central Islip - Clothing, Grocery, Furniture, Etc
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- Doctors, Physicians & Surgeons, Central Islip
- Document Imaging & Management, Central Islip
- Doors & Door Frames, Central Islip - Exterior, Interior, French, Front Entry, Patio, Storm, Garage & Sliding Glass Doors
- Drainage Contractors, Central Islip - Install & Repair Drainage Systems
- Drinking Establishments, Central Islip
- Driving Proficiency Testing, Central Islip
- Drugs, Pharmaceutical Products & Toiletries - Wholesale & Manufacturers, Central Islip
- Dry Cleaning & Laundry, Central Islip - Dry Cleaners
- Drywall Contractors, Central Islip - Drywall Repair & Installation Services
- Drywall, Insulation & Plaster Contractors, Central Islip - Installation & Repair Services
- Dwelling Operators Except Apartment, Central Islip
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