- Laboratories Medical, Central Islip
- Laminated Plastic Plate & Sheet Manufacturers, Central Islip
- Land Planning Services, Central Islip
- Land Surveyor, Central Islip - Land Surveying Services
- Landscape Contractors & Designers, Central Islip
- Landscaping, Central Islip
- Latin American Restaurants, Central Islip
- Laundromats & Dry-Cleaning, Coin-Operated, Central Islip
- Laundry Self Service, Central Islip
- Lawn & Garden Equipment & Supplies, Central Islip
- Lawn & Garden Sprinkler Systems, Central Islip
- Lawyers & Attorneys, Central Islip
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- Legal Professionals, Central Islip
- Libraries, Central Islip
- Licensed Counselors, Central Islip
- Lighting Consultants & Designers, Central Islip
- Lighting Fixtures & Equipment, Central Islip
- Limousine Service, Central Islip
- Liquor Stores, Central Islip
- Litigation / Trial Attorneys & Lawyers, Central Islip
- Lodging, Central Islip
- Long Haul Trucking Companies, Central Islip
- Lp Gas Equipment & Supplies, Central Islip
- Lutheran Church, Central Islip
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