- Laboratories Medical, Orangeburg
- Landscape Contractors & Designers, Orangeburg
- Landscaping, Orangeburg
- Laundry Self Service, Orangeburg
- Lawn Mower Repair & Blade Sharpening Service, Orangeburg
- Lawyers & Attorneys, Orangeburg
- Legal Professionals, Orangeburg
- Libraries, Orangeburg
- Lighting Fixtures & Equipment, Orangeburg
- Liquor Stores, Orangeburg
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- Livestock, Orangeburg
- Livestock Dealers, Orangeburg
- Locksmiths, Orangeburg - Residence, Commercial, Safe & Auto Car Locksmith
- Lodging, Orangeburg
- Lodging Services, Orangeburg
- Long Haul Trucking Companies, Orangeburg
- Lp Gas Equipment & Supplies, Orangeburg
- Lumber & Lumber Products, Orangeburg
- Lumber & Lumber Products, Orangeburg
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