- Obstetricians & Gynecologists, Orangeburg - Ob-Gyn Doctors, Physicians & Surgeons (Obstetrics & Gynecology)
- Off Road Vehicles, Orangeburg
- Off Road Vehicles Parts & Accessories, Orangeburg
- Office Supplies, Equipment & Office Furniture Stores, Orangeburg
- Oil Change & Lubrication, Orangeburg - Auto Oil & Quick Lube
- Optical Stores - Eyeglasses, Lenses & Sunglasses, Orangeburg
- Orthodox Churches, Orangeburg
- Orthopedists, Orangeburg - Orthopedic Surgery Doctors, Physicians & Surgeons
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