- Occupational Health Care Professionals, Tonawanda
- Occupational Therapy, Tonawanda - Occupational Health Specialists
- Off Road Vehicles, Tonawanda
- Off Road Vehicles Parts & Accessories, Tonawanda
- Office Supplies, Equipment & Office Furniture Stores, Tonawanda
- Oil & Petroleum Products, Tonawanda - Merchant, Wholesalers, etc
- Oil Change & Lubrication, Tonawanda - Auto Oil & Quick Lube
- Oil Handling Equipment & Supplies, Tonawanda
- Oil Industry & Oil Field Equipment & Services, Tonawanda - Oil Companies
- Oil Petroleum Wholesale, Tonawanda
- Oil Refinery, Tonawanda
- Oils - Fuel - Alternative, Tonawanda
- Oils Recycling, Tonawanda
- Ophthalmologists, Tonawanda - Eye Doctors, Physicians & Surgeons (Ophthalmology)
- Optical Goods Manufacturers, Tonawanda
- Optical Stores - Eyeglasses, Lenses & Sunglasses, Tonawanda
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- Opticians, Tonawanda
- Optometrists, Tonawanda - Eye Doctors, Physicians & Surgeons (Optometry)
- Optometry Clinics, Tonawanda - Eye Clinics
- Oral Surgeon, Tonawanda - Dentists - Oral & Maxillofacial Surgeons
- Ornamental Nursery, Tonawanda
- Ornamental Nursery Services, Tonawanda
- Orthodontist, Tonawanda - Teeth Straightening, Invisalign & Dental Braces
- Orthopedic & Prosthetic Appliances & Shoes, Tonawanda - Orthopedic Shoes
- Orthopedic Shoes, Tonawanda
- Orthotics and Prosthetics, Tonawanda
- Other Building Materials & Supplies, Tonawanda
- Other Electrical Products, Tonawanda
- Other Lodging, Tonawanda
- Outdoor & Lawn & Garden Equipment Repair & Service, Tonawanda
- Outdoor Equipment & Accessories, Tonawanda
- Overhead Door, Tonawanda
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